Scholarship Project

William Thierfelder

Associate Professor of Biology

Director, Edward P. Hammons Center for Scientific Studies

22 Results

Peer-Reviewed Journal Article(s)

• "NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells," Nature Genetics, Vol. 47 Issue 6, 607–614. (May 2015) (with Steven W Paugh, Erik J Bonten, Daniel Savic, Laura B Ramsey, Prajwal Gurung, R K Subbarao Malireddi, Marcelo Actis, Anand Mayasundari, Jaeki Min, David R Coss, Lucas T Laudermilk, John C Panetta, J Robert McCorkle, Yiping Fan, Kristine R Crews, Gabriele Stocco, Mark R Wilkinson, Antonio M Ferreira, Cheng Cheng, Wenjian Yang, Seth E Karol, Christian A Fernandez, Barthelemy Diouf, Colton Smith, J Kevin Hicks, Alessandra Zanut, Audrey Giordanengo, Daniel Crona, Joy J Bianchi, Linda Holmfeldt, Charles G Mullighan, Monique L den Boer, Rob Pieters, Sima Jeha, Thomas L Dunwell, Farida Latif, Deepa Bhojwani, William L Carroll, Ching-Hon Pui, Richard M Myers, R Kiplin Guy, Thirumala-Devi Kanneganti, Mary V Relling & William E Evans)
• "PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity," Human Molecular Genetics, Vol. 21, Issue 21, 4793–4804. (July 2012) (with Gabriele Stocco, Wenjian Yang, Kristine R. Crews, Giuliana Decorti, Margherita Londero, Raffaella Franca, Marco Rabusin, Maria Grazia Valsecchi, Deqing Pei, Cheng Cheng, Steven W. Paugh, Laura B. Ramsey, Barthelemy Diouf, Joseph Robert McCorkle, Terreia S. Jones, Ching-Hon Pui, Mary V. Relling, William E. Evans)
• "Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells," NatureMedicine, Vol. 17, Issue 10, 1298–1303. (September 2011) (with Barthelemy Diouf, Qing Cheng, Natalia F. Krynetskaia, Wenjian Yang, Meyling Cheok, Deqing Pei, Yiping Fan, Cheng Cheng, Evgeny Y. Krynetskiy, Hui Geng, Siying Chen, Charles G. Mullighan, James R. Downing, Peggy Hsieh, Ching-Hon Pui, Mary V. Relling, William E. Evans)
• "Absence of an essential role for TSLPR in murine B cell development," Molecular and Cellular Biology, Vol. 24, Issue 6, 2584-2592. (March 2004) (with Nick Carpino, Ming-shi Chang, Chris Saris, Steven J Turner, Steven F Ziegler, James N Ihle)
• "Interleukin-4 and –13 induce upregulation of the murine macrophage 12/15-activity: evidence for the involvement of transcription factor STAT6," Blood, Vol. 92, Issue 7, 2503-2510. (October 1998) (with D. Heydeck, L. Thomas, K. Schnurr, F. Trebus, J. N. Ihle, H. Kühn)
• "Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells," Nature, Vol. 382, Issue 6587, 171–174. (July 1996) (with J. M. van Deursen, K. Yamamoto, R A Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. Vignali, P. C. Doherty, G. C. Grosveld, J. N. Ihle)
• "Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response," Molecular and Cellular Biology, Vol. 16 Issue 4, 1622-1631. (April 1996) (with F. W. Quelle, D. Wang, T. Nosaka, D. Stravopodis, Y Weinstein, J. N. Ihle)
• "Defective lymphoid development in mice lacking Jak3," Science., Vol. 270, Issue 5237, 800-802. (November 1995) (with T. Nosaka, J. M. van Deursen, R. A. Tripp, B A. Witthuhn, A. P. McMickle, P. C. Doherty, G. C. Grosveld, J. N. Ihle)
• "Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor," Journal of Biological Chemistry, Vol. 270, Issue 35, 20775-20780. (September 1995) (with F. W. Quelle, B. A. Witthuhn, B. Tang, S. Cohen, J. N. Ihle)
• "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis," Molecular and Cellular Biology, Vol. 15, Issue 6, 3336-3343. (June 1995) (with F. W. Quelle, K. Shimoda, C. Fischer, A. Kim, S. M. Ruben, J. L. Cleveland, J. H. Pierce, A. D. Keegan, K. Nelms, et al.)
• "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation," Molecular and Cellular Biology, Vol. 14, Issue 7, 4342-4349. (July 1994) (with K. Yamamoto, F. W. Quelle, B. L. Kreider, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, O. Silvennoinen, J. N. Ihle)
• "Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a Cl locus in Burkitt lymphoma cells," Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 22, 6922-6926. (November 1983) (with C. M. Croce, J. Erikson, K. Nishikura, J. Finan, G. M. Lenoir, P. C. Nowell)

Review Article(s)

• "Signaling by the cytokine receptor superfamily," Annals of the New York Academy of Sciences, Vol. 865, Issue 1, 1-9. (December 1998) (with J N Ihle, S Teglund, D Stravopodis, D Wang, J Feng, E Parganas)
• "Jaks and Stats in cytokine signaling," Stem Cells, Vol. 15 Suppl 1, 105-111. (April 1997) (with J N Ihle, T Nosaka, F W Quelle, K Shimoda)
• "Signaling by the cytokine receptor superfamily: JAKs and STATs," Trends in Biochemical Sciences, Vol. 19, Issue 5, 222-227. (May 1994) (with J N Ihle, B A Witthuhn, F W Quelle, K Yamamoto, B Kreider, O Silvennoinen)

Presentation(s)

• "Thyroid hormone regulation during inflammation." Tri Beta Faculty Researcher of the Year presentation, Union University, Jackson, TN. (May 2018)
• "Genome-wide identification of determinants of leukemia cell sensitivity to mercaptopurine." (with Stocco G, Wenjian Y, Crews K, Paugh S, Diouf B, Mc Corkle R, Den Boer M, Relling MV, Pieters R, Evans WE)
  National Monothematic Symposium of the Italian Society of Pharmacology on Cancer Pharmacogenomics, Grado, Italy. (October 2011)
• "Genome-wide identification of determinants of leukemia cell sensitivity to mercaptopurine." (with Stocco G, Yang W, Crews K, Paugh S, Diouf B, Mc Corkle R, Den Boer M, Relling M, Pieters R, Evans WE.)
  Meeting of the Italian Society of Pharmacology, Bologna, Italy. (September 2011)
• "Genetic determinants of severe gastrointestinal toxicity during therapy with 6-mercaptopurine and methotrexate in pediatric acute lymphoblastic leukemia." (with Stocco G, Yang W, Crews K, Paugh S, Diouf B, McCorkle R, Decorti G, Londero M, Franca R, Valsecchi M.G., Rabusin M, Relling MV, Pui C-H, Evans WE.)
  Meeting of the Italian Society of Pharmacology, Bologna, Italy. (September 2011)
• "Signaling by the cytokine receptor superfamily." (with Ihle JN, Teglund S, Stravopodis D, Wang D, Feng J, Parganas E. )
  Germany Symposium, Freiburg, Germany. (September 1997)
• "Stat4 is required for IL-12-induced responses of natural killer and T cells" (with van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Cardin RD, Brooks JW, Vignali DAA, Doherty PC, Grosveld GC, and Ihle JN)
  Keystone Symposia, Growth Control, Keystone, CO. (January 1997)
• "Epo and IL-3 induce GAS binding activities distinct from STAT1, but do not alter STAT1 activation of IRF-1 gene expression" (with Quelle FW, Schindler C, Miura O, Kreider BL, Snyder L, and Ihle JN)
  Tenth Annual Meeting on Oncogenes, Hood College, Frederick, MD. (January 1994)