Biology

William Thierfelder

Associate Professor of Biology

Director, Edward P. Hammons Center for Scientific Studies

Office: WH 112B, 731-661-5252
wthierfelder@uu.edu

Mailing Address:
1050 Union University Dr
Jackson, TN 38305

University Profile Scholarship Profile

Undergraduate Research Mentor

• Sydney Zemke. Novel Specific Primer Design for Alligator mississippiensis in Preparation of Environmental DNA (eDNA) Survey Research (with Micah Fern)
• Kayla Fisher. The effect of inflammatory stimuli on expression of deoidinase enzymes in mammalian cell lines.
• Stephen Luyakoh. Investigation of the regulation of enzymes DIO2 and DIO3 in T4 to T3 conversion by LPS induction. Co-mentor Jim Mahan, Ph.D.
• Chance Mattox. Regulation of deiodinase enzymes in response to oxidative stress in cultured cell lines. Co-mentor Jim Mahan, Ph.D.

Original Articles

• Paugh, SW, Thierfelder, WE, Bonten, EJ, Malireddi, RKS, Actis, M, Laudermilk, LT, Panetta, C, McCorkle, JR, Stocco, GS, Wilkinson, M, Coss, D, Ferreira, AM, Crews, KR, Cheng, C, Yang, W, Fernandez, C, Ramsey, LB, Diouf, B, Smith, C, Giordanengo, AK, Crona, D, denBoer, ML, Pieters, R, Jeha, S, Latif, F, Pui, C-H, Guy, K, Kanneganti, T-D, Relling, MV, and Evans, WE. Caspase 1 cleaves the glucocorticoid receptor and its over-expression causes steroid resistance in acute lymphoblastic leukemia. Manuscript in preparation (2014).
• Stocco, GS, Yang, W, Crews, KR, Thierfelder, WE, Decorti, G, Londero, M, Franca, R, Rabusin, M, Valsecchi, MG, Pei, D, Cheng, C, Paugh, SW, Ramsey, LB, Diouf, B, McCorkle, JR, Jones, TS, Pui, C-H, Relling, MV, and Evans, WE. PACSIN2 polymorphism influences TPMT activity and mercaptopurine related gastrointestinal toxicity. Hum Mol Genet (2012) November 1;21(21): 4793-804. doi:10.1093/hmg/dds302. Epub 2012 Jul 30.
• Diouf, B, Cheng, Q, Krynetskaia, NF, Yang, W, Cheok, M, Pei, D, Fan, Y, Cheng, C, Krynetskiy, EY, Geng, H., Chen, S., Thierfelder, WE, Mullighan, CG, Downing, JR, Hsieh, P., Pui, C-H., Relling, MV, and Evans, WE. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human cancer cells. Nature Medicine 17:1298 - 1303 (2011), doi:10.1038/nm.2430.
• Carpino N, Thierfelder WE, Chang M, Saris C, Turner SJ, Ziegler SF, and Ihle JN. Absence of an essential role for TSLPR in murine B cell development. Mol Cell Biol 24(6): 2584 - 2592 (2004).
• Thierfelder WE. Why online classes? A response from an observer in the sciences. The CyberPeer Vol. 1, No. 2. Memphis, TN: Crichton College, The Center for Distance Education and Learning Technologies (2000).
• Heydeck D, Thomas L, Schnurr K, Trebus F, Thierfelder WE, Ihle JN and Kuhn H. Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-activity: evidence for the involvement of transcription factor STAT6. Blood 92(7): 2503 - 2510 (1998).
• Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DAA, Doherty PC, Grosveld GC, and Ihle JN. Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells. Nature 382(6587): 171 - 174 (1996).
• Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, and Ihle JN. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 16: 1622 - 1631 (1996).
• Nosaka T, van Deursen JMA, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld, GC, and Ihle JN. Defective lymphoid development in mice lacking Jak3. Science 270: 800 - 802 (1995).
• Quelle FW, Thierfelder W, Witthuhn BA, Tang B, Cohen S, and Ihle JN. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J Biol Chem 270: 20775 - 20780 (1995).
• Quelle FW, Shimoda K, Thierfelder W, Fischer C, Kim A, Ruben SM, Cleveland JL, Pierce JH, Keegan AD, Nelms K, Paul WE, and Ihle JN. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol 15: 3336 - 3343 (1995).
• Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, Copeland NG, Silvennoinen O, and Ihle JN. Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol Cell Biol 14: 4342 - 4349 (1994).
• Croce CM, Thierfelder W, Erikson J, Nishikura K, Finan J, Lenoir GM, and Nowell PC. Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C locus in Burkitt lymphoma cells. Proc Natl Acad Sci USA 80: 6922 - 6926 (1983).

Book Chapters and Review Articles

• Ihle JN, Thierfelder W, Teglund S, Stravopodis D, Wang D, Feng J, Parganas E. Signaling by the cytokine receptor superfamily. Ann N Y Acad Sci 865: 1 - 9 (1998).
• Ihle JN, Stravopodis D, Parganas E, Thierfelder W, Feng J, Wand D, and Teglund S. The roles of Jaks and Stats in cytokine signaling. Cancer J Sci Amer 3(6A Suppl): 1 - 8 (1998).
• Ihle JN, Nosaka T, Thierfelder W, Quelle FW, and Shimoda K. Jaks and Stats in cytokine signaling. Stem Cells 15 Suppl.1: 105 - 111 (1997).
• Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, and Silvennoinen O. Signaling by the cytokine receptor superfamily: Jaks and STATs. Trends Biochem Sci 19: 222 - 227 (1994).
• Thierfelder W, Cummings P, Fraser P, Curtis PJ. Expression of carbonic anhydrases I and II in mouse erythropoiesis. In: S Dodgson, ed. The Carbonic Anhydrases. Plenum Publishing Corp., New York, NY, pp. 209 - 214 (1991).

Presentations

• ORAL SESSION: Stocco G, Wenjian Y, Crews K, Thierfelder W, Paugh S, Diouf B, Mc Corkle R, Den Boer M, Relling MV, Pieters R, Evans WE. Genome-wide identification of determinants of leukemia cell sensitivity to mercaptopurine. National Monothematic Symposium of the Italian Society of Pharmacology on Cancer Pharmacogenomics, Grado (Italy) October 2011.
• POSTER SESSIONS:
  • Stocco G, Yang W, Crews K, Thierfelder W, Paugh S, Diouf B, Mc Corkle R, Den Boer M, Relling M, Pieters R, Evans WE. Genome-wide identification of determinants of leukemia cell sensitivity to mercaptopurine. Meeting of the Italian Society of Pharmacology, Bologna (Italy) September 2011.
  • Stocco G, Yang W, Crews K, Thierfelder W, Paugh S, Diouf B, McCorkle R, Decorti G, Londero M, Franca R, Valsecchi M.G., Rabusin M, Relling MV, Pui C-H, Evans WE. Genetic determinants of severe gastrointestinal toxicity during therapy with 6-mercaptopurine and methotrexate in pediatric acute lymphoblastic leukemia. Meeting of the Italian Society of Pharmacology, Bologna (Italy) September 2011.
• Ihle JN, Thierfelder W, Teglund S, Stravopodis D, Wang D, Feng J, Parganas E. Signaling by the cytokine receptor superfamily. Freiburg, Germany Symposium (September, 1997).
• Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Cardin RD, Brooks JW, Vignali DAA, Doherty PC, Grosveld GC, and Ihle JN. Stat4 is required for IL-12-induced responses of natural killer and T cells. Keystone Symposia, Growth Control, Keystone, CO (1997).
• Thierfelder WE, Quelle FW, Schindler C, Miura O, Kreider BL, Snyder L, and Ihle JN. Epo and IL-3 induce GAS binding activities distinct from STAT1, but do not alter STAT1 activation of IRF-1 gene expression. Tenth Annual Meeting on Oncogenes, Hood College, Frederick, MD (1994).